Hyaluronic Acid & Vitamin B5: Powerhouse Hydration Duo for Mature Skin
As we get older, one of the first changes we notice in our skin is a loss of hydration. It may start feeling drier, fine lines become more noticeable, and the plump, dewy glow we once had in our twenties starts to fade. This isn’t just about drinking more water – our skin’s natural ability to retain moisture slows down due to a decline in hyaluronic acid production and a weakening skin barrier.
That’s where the powerful skincare combination of Hyaluronic Acid (HA) and Panthenol (Vitamin B5) comes in. These two powerhouse ingredients work together to restore moisture levels, strengthen the skin barrier, and improve elasticity, making them essential in any skincare routine for anyone aged 30 and above.
What is Hyaluronic Acid & Why Does It Matter?
Hyaluronic Acid is often hailed as the ultimate hydrating ingredient, and for good reason. It’s a humectant, meaning it draws moisture into the skin, keeping it soft and supple. Naturally occurring in our skin, HA can hold up to 1,000 times its weight in water, helping to plump fine lines and improve overall texture.
However, as we age, our skin’s ability to produce and retain HA declines, leading to dehydration, dullness, and visible wrinkles. This is why applying topical HA becomes an essential step in maintaining youthful-looking skin. The right HA-based serums don’t just add moisture – they actively replenish and strengthen your skin’s hydration levels.
Why Panthenol (Vitamin B5) is the Perfect Partner
Hyaluronic Acid pulls moisture into the skin, but without a secondary ingredient to help seal that hydration in, it can evaporate quickly – especially in drier climates. Many people notice that while HA alone gives instant plumpness, the effect fades quickly if a barrier-repairing ingredient isn’t included in the routine. This is where Vitamin B5 steps in. By strengthening the skin barrier and reducing transepidermal water loss (TEWL), Panthenol helps keep that hydration locked in for longer-lasting benefits.
The combination of these two ingredients:
- Deeply hydrates by drawing and retaining moisture.
- Soothes irritation and redness by calming inflammation.
- Improves elasticity for a firmer, healthier complexion.
- Strengthens the skin barrier, reducing moisture loss.
- Enhances skin’s resilience, helping it better recover from environmental damage.
The Ideal Routine: How to Use Hyaluronic Acid & Vitamin B5
For the best results, follow these key steps:
- Apply Hyaluronic Acid to damp skin – Since HA is a humectant, it works best when applied to slightly moist skin.
- Layer with a Vitamin B5-rich product – This locks in hydration and prevents water loss. Better yet, use a product that has both ingredients in together (more on those in a bit!)
- Always finish with a moisturiser – Sealing in hydration ensures long-lasting results.
- Use SPF daily – Hydration is important, but UV protection is the key to slowing down skin aging.
Incorporating these two ingredients into your skincare routine can help revitalise dry, tired skin and promote a youthful glow – without the need for heavy, occlusive creams.
Our Favourite Hydrating Products
The best products combine high-potency ingredients with stable, well-absorbed formulations that deliver long-lasting hydration and barrier support. Here are our top recommendations for incorporating this hydration-boosting duo into your routine.
DP Dermaceuticals Hyla Active
Why we love it:
This deeply hydrating serum contains both Hyaluronic Acid and Vitamin B5/Panthenol, making it the perfect choice for those looking to restore hydration while supporting the skin barrier. It’s also ideal for post-procedure care, helping to speed up skin recovery.
Medik8 Hydr8 B5 Serum
Why we love it:
A lightweight yet powerful daily serum that combines multi-weight HA and Vitamin B5 to provide deep hydration without feeling greasy. Perfect for layering under other skincare products.
Medik8 Hydr8 B5 Intense Serum
Why we love it:
This is the upgraded version of the original Hydr8 B5, with added NMFs (Natural Moisturising Factors) and saskatoon berry extract, which enhances HA’s effects for even longer hydration.
Mesoestetic Hydracream Fusion
Why we love it:
A hydrating and barrier-repairing cleansing cream that doesn’t strip the skin. Ideal for dry or sensitive skin types needing gentle cleansing without dehydration.
Mesoestetic Hydratonic Mist
Why we love it:
A soothing and hydrating toner that preps the skin to absorb serums more effectively. Packed with moisturising agents to keep skin soft and balanced.
Thoughts from Dr Nadja Haub
Hyaluronic Acid and Vitamin B5 are a perfectly matched duo for keeping your skin healthy, plump, and hydrated – especially as we age. Whether you’re looking to restore moisture after sun exposure, combat dryness, or improve elasticity, this ingredient combination is a must-have in any skincare routine.
By choosing professional-grade products that contain both HA and B5, you can experience longer-lasting hydration and improved skin resilience.
